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KMID : 1103720110640020109
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Journal of the Korean Society of Radiology
2011 Volume.64 No. 2 p.109 ~ p.112
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Acute Cerebral Infarction after FK 506 Administration in a Kidney Transplantation Recipient: A Case Report
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Lim Ji-Kyung
Byun Woo-Mok
Kim Jae-Woon
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Abstract
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FK506 is widely used as a potent immunosuppressive agent following organ transplantation. However, the use of FK506 is associated with a wide spectrum of neurotoxicity. FK506-induced cerebral infarctions have rarely been reported. We report here on a case of the acute cerebral infarction caused by vasospasm after FK506 administration in a kidney transplantation recipient. There were areas with increased signal intensity on the diffusion-weighted image. The areas showing increased signal intensity on the diffusion- and T2-weighted images demonstrated decreased signal intensity on the apparent diffusion coefficient mapping. MR angiography showed diffuse stenosis in both the anterior and middle cerebral arteries.
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KEYWORD
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Tacrolimus, Neurotoxicity Syndrome, Stroke, Kidney Transplantation, Neurotoxins
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